Don Wiley's Publications

1. Steitz, T., Wiley, D.C., Lipscomb, W.N. The Structure of Aspartate Tanscarbamylase, I. A Molecular Twofold Axis in the Complex with Cytidine Triphosphate, PNAS, 58, 1859-1861, 1967.
   
   
2. Wiley, D.C. and Lipscomb, W.N. Crystallographic Determination of the Symmetry of Aspartate Transcarbamylase, Nature (London) 218, 1119, 1968.
   
   
3. Wiley, D.C. The 5.5 Å Structure of the Regulatory Enzyme, Aspartate Transcarbamylase, Ph.D. Thesis, Harvard University, June 1971.
   
   
4. Wiley, D.C., Evans, D.R., Warren, S.G., McMurray, C.H., Edwards, B.F.P., Franks, W.A., and Lipscomb, W.N. The 5.5 Å Resolution Structure of the Regulatory Enzyme, Aspartate Transcarbamylase, Cold Spring Harbor Symposium on Quantitative Biology 36, 285, 1971.
   
   
5. Stolow, R.D., Giants, T.W., Krikorian, R.R., Litchman, M.A., and Wiley, D.C. The Synthesis and Configuration of cis-2, 6-Dimethyl-l, 4-cyclohexanedione, r- 2,c- 6-Dimethyl-c-r- hydroxycyclohexamone, and Two Related Diols, J. Organic Chem. 37, 2894, 1972.
   
   
6. Evans, D.R., Warren, S.G., Edwards, B.F.P., McMurray, C.H., Bethge, P.H., Wiley, D.C., and Lipscomb, W.N. The Aqueous Central Cavity in Aspartate Transcabamylase from E. coli, Science 179, 683, 1973.
   
   
7. Warren, S.G., Edwards, B.F.P., Evans, D.R., Wiley, D.C., and Lipscomb, W.N. Aspartate Transcarbamylase from E. coli. Electron Density at 5.5 Å Resolution, Proc. Natl. Acad. Sci. USA 70, 1117, 1973.
   
   
8. Edwards, B.F.P., Evans, D.R., Warren, S.G., Monaco, H.L., Landfear, S.M., Eisele, G., Crawford, J.L., Wiley, D.C., and Lipscomb, W.N. Complex of Aspartate Transcarbamylase from Escherichia coli and its Allosteric Inhibitor, Cytidine Trephosphate: Electron Density at 5.5 Å Resolution, Proc. Natl. Acad. Sci. USA 71, 4437, 1974.
   
   
9. Lipscomb, W.N., Evans, D.R., Edwards, B.F.P., Warren, S.G., Pastra- Landis, S., and Wiley, D.C. Three- Dimensional Structures at 5.5 Å Resolution and Regulatory Processes in Aspartate Transcarbamylase from E. coli, J. Supra. Structure 2, 82, 1974.
   
   
10. Wiley, D.C., Skehel, J.J., and Waterfield, M. Evidence from Studies with a Cross-linking Reagents that the Haemagglutinin of Influenza Virus is a Trimer, Virology 79, 446- 448, 1977.
    
    
11. Wiley, D.C. and Skehel, J.J. Crystallization and X-ray Diffraction Studies on the Haemagglutinin Glycoprotein from the Membrane of Influenza Virus, J. Mol. Biol. 112, 343-347, 1977.
    
    
12. Wiley, D.C. and Skehel, J.J. Preliminary Studies of the Membrane Associated Portion of the Haemagglutinin in Topics in Infectious Diseases, Vol. 3, 135-138 (eds. Laver, W. G., Bachmayer, H. and Weil, R.), Springer-Verlag, Vienna, l978.
    
    
13. Wiley, D.C., Flanagan, M.T., and Skehel, J.J. Studies on the Structure of the Haemagglutinin, in Topics in Infectious Diseases Vol. 3, 131-134 (eds. Laver, W. G., Bachmayer, H. and Weil, R.), Springer-Verlag, Vienna, 1978.
    
    
14. Wiley, D.C. and von Bonsdorff, C.H. Three-Dimensional Crystals of the Lipid Enveloped Semliki Forest Virus, J. Mol. Biol. 120, 375-379, 1978.
    
    
15. Wilson, I.A., Skehel, J.J., and Wiley, D.C. Structural Studies on the Haemagglutinin Glycoprotein of Influenza Virus, in Structure and Variation in Influenza Virus (eds. Laver, G. and Air, G.), Elsevier-North Holland, New York. 339-349, 1980.
    
    
16. Skehel, J.J., Waterfield, M.D., McCauley, J., Elder, K. and Wiley, D.C. Studies on the Structure of the Haemagglutinin, Philosophical Transactions of the Royal Society of London, B. 288, 335, 1980.
    
    
17. Clardy, J., Finer-Moore, J., Weiler, L. and Wiley, D.C. The Structure of Acumycin a 16- Membered Ring Macrolide Antibiotic, Tetrahedron 37, 91-97, 1981.
    
    
18. Wilson, I.A., Skehel, J.J., and Wiley, D.C. Structure of the Haemagglutinin Membrane Glycoprotein of Influenza Virus at 3 Å Resolution, Nature 289, 366-373, 1981.
    
    
19. Wiley, D.C., Wilson, I.A., and Skehel, J.J. Structural Identification of the Antibody-Binding Sites of Hong Kong Influenza Haemagglutinin and their Involvement in Antigenic Variation, Nature 289, 373-378, 1981.
    
    
20. Skehel, J.J., Bayley, P.M., Brown, E.B., Martin, S.R., Waterfield, M.D., White, J.M., Wilson, I.A., and Wiley, D.C. Changes in the Conformation of Influenza Virus Haemagglutinin at the pH Optimum of Virus-Mediated Membrane Fusion, Proc. Natl. Acad. Sci. USA 79, 968- 972, 1982.
    
    
21. Skehel, J.J., Douglas, A.R., Wilson, I.A., and Wiley, D.C. Antigenic Variation in the Influenza A, Hong Kong) Viruses, in Virus Persistence (eds. Mahy, B.W.J., Minson, A.C. and Darby, G.K.), The Society for General Microbiology, Symposium 33, Cambridge University Press), 215-226, 1982.
    
    
22. Skehel, J.J., Daniels, R.S., Douglas, A.R., Knossow, M., Paulson, J.C., Rogers, G.N., Waterfield, M.D., Wilson, I.A., and Wiley, D.C. Studies on the Structure and Activities of Influenza Virus Haemagglutinin, Progress in Medical Virology, Vol. III, Martinus Nijhoff/Dr. W. Junk Pubs.), 217- 225, 1983.
    
    
23. Wrigley, N.G., Brown, E.B., Daniels, R.S., Douglas, A.R., Skehel, J.J., and Wiley, D.C. Electron Microscopy of Influenza Haemagglutinin Monoclonal Antibody Complexes, Virology 131, 308, 1983.
    
    
24. Krystal, M., Young, J.F., Palese, P., Wilson, I.A., Skehel, J.J., and Wiley, D.C. Sequential Mutations in Hemagglutinins of Influenza B Virus Isolates: Definition of Antigenic Domains, Proc. Natl. Acad. Sci. USA 80, 4527-4531, 1983.
    
    
25. Rogers, G.N., Paulson, J.C., Daniels, R.S., Skehel, J.J., Wilson, I.A., and Wiley, D.C. Single Amino Acid Substitutions in Influenza Haemagglutinin Change Receptor Binding Specificity, Nature 304, 76-78, 1983.
    
    
26. Wilson, I.A., Ladner, R.C., Skehel, J.J., and Wiley, D.C. The Structure and Role of the Carbohydrate Moieties of Influenza Virus Haemagglutinin, Biochem. Soc. Trans. 11, 145-147, 1983.
    
    
27. Skehel, J.J., Daniels, R.S., Douglas, A.R., and Wiley, D.C. Antigenic and Amino Acid Sequence Variations in the Haemagglutinins of Type A Influenza Viruses Recently Isolated from Human Subjects, Bulletin of World Health Organization 61, 671-676, 1983.
    
    
28. Daniels, R.S, Douglas, A.R., Skehel, J.J., and Wiley, D.C. Analyses of the Antigenicity of Influenza Haemagglutinin at the pH Optimum for Virus- Mediated Membrane Fusion, J. Gen. Virol. 64, 1657-1662, 1983.
    
    
29. Wiley, D.C. and Skehel, J.J. The Three-Dimensional Structure and Antigenic Variation of the Influenza Virus Haemagglutinin, in Microbiologia 83, Vol II, Proceedings of the IXth National Congress of Microbiology, Spanish Society of Microbiology, Valladolid, Spain, 107- 111, 1983.
    
    
30. Skehel, J.J. and Wiley, D.C. Targets for the Design of Antiviral Agents: Targets in Orthomyxoviruses, in NATO Advanced Study Institute - Targets for the Design of Antiviral Agents (eds. E. de Clerq and R. Walker), Plenum Press, 1983.
    
    
31. Skehel, J.J. and Wiley, D.C. Antigenic Variation in Influenza Viruses, in Proceedings of WHO Symposium on Modern Vaccination, Geneva, pp. 19-23, 1983.
    
    
32. Wilson, I.A., Skehel, J.J., and Wiley, D.C. The Three- Dimensional Structure of a Viral Antigen: The Haemagglutinin Glycoprotein of Influenza Virus, Cold Spring Harbor Press, 1983.
    
    
33. Daniels, R.S., Douglas, A.R., Skehel, J.J., Waterfield, M.D., Wilson, I.A. and Wiley, D.C. Studies of the Influenza Virus Haemagglutinin in the pH 5 Conformation in The Origin of Pandemic Influenza Viruses (ed. W.G. Laver), Elsevier, NY, 1-7, 1983.
    
    
34. Daniels, R.S., Douglas, A.R., Gonzales-Scarano, F., Palu, G., Skehel, J.J., Brown, E., Knossow, M., Wilson, I.A. and Wiley, D.C. Antigenic Structure of Influenza Virus Haemagglutinin in The Origin of Pandemic Influenza Viruses. (ed. W.G. Laver), Elsevier, NY, 8- 18, 1983.
    
    
35. Wilson, I.A., Skehel, J.J., and Wiley, D.C. The Structure and Function of the Haemagglutinin Glycoprotein of Influenza Virus, in X-ray Crystallography and Drug Action (eds. Horn, A. S. and DeRanter, C. J.), Clarendon Press, Oxford, 222-234, 1984.
    
    
36. Skehel, J.J., Daniels, R.S., Douglas, A.R., Wang, M., Knossow, M., Wilson, I.A. and Wiley, D.C. Studies on the Haemagglutinin, The Molecular Virology and Epidemiology of Influenza. (eds. Stuart Harris, C. and Potter, C.W), Academic Press, London, New York and Orlando, 61-75, 1984.
    
    
37. Wiley, D.C., Wilson, I.A., and Skehel, J.J. The Hemagglutinin Membrane Glycoprotein of Influenza Virus in Biological Macromolecules and Assemblies, Vol. I: Viral Structures (eds. Jurnak, F. and McPherson, A.), 299-336, John Wiley and Sons, Inc., New York, 1984.
    
    
38. Skehel, J.J., Stevens, D.J., Daniels, R.S., Douglas, A.R., Knossow, M., Wilson, I.A., and Wiley, D.C. A Carbohydrate Side-Chain on the Haemagglutinins of Hong Kong Influenza Viruses Inhibits Recognition by a Monoclonal Antibody, Proc. Natl. Acad. Sci. USA 81, 1779-1783, 1984.
    
    
39. Freymann, D., Metcalf, P., Turner, M., and Wiley, D.C. 6 Å Resolution X-ray Structure of a Variable Surface Glycoprotein from Trypanosoma brucei. Nature 311, 167-169, 1984.
    
    
40. Knossow, M., Daniels, R.S., Douglas, A.R., Skehel, J.J., and Wiley, D.C. Three- dimensional Structure of an Antigenic Mutant of the Influenza Virus Haemagglutinin, Nature 311, 678-680, 1984.
    
    
41. Daniels, R.S., Douglas, A.R., Skehel, J.J., Wiley, D.C., Naeve, C.W., Webster, R.G., Rogers, G.N., and Paulson, J.C. Antigenic Analyses of Influenza Virus Haemagglutinins with Different Receptor Binding Specificities, Virology 138, 174- 177, 1984.
    
    
42. Rott, R., Orlich, M., Klenk, H.-D., Wang, M.L., Skehel, J.J., and Wiley, D.C. Studies on the Adaptation of Influenza Viruses to MDCK Cells, EMBO J. 3, 3329-3332, 1985.
    
    
43. Wiley, D.C. Viral Membranes, in Virology (ed. B.N. Fields et al.), Raven Press, New York, 45-68, 1985.
    
    
44. Wiley, D.C. and Skehel, J.J. The Membrane Fusion Activity of the Influenza Virus Haemagglutinin Glycoprotein, in Modern Trends of Colloid Science in Chemistry and Biology (ed. Hans-Friedrick Eicke), International Symposium of Colloid and Surface Science) Birkhauser- Verlag Publishers, Basel, 231-239, 1985.
    
    
45. Rogers, G.N., Daniels, R.S., Skehel, J.J., Wiley, D.C., Wang, X.F., Higa, H.H., and Paulson, J.C. Host-mediated Selection of Influenza Virus Receptor Variants. J. Biol. Chem. 260, No. 12, 7362-7367, 1985.
    
    
46. Daniels, R.S., Downie, J.C., Hay, A.J., Knossow, M., Skehel, J.J., Wang, M.L. and Wiley, D.C. "Fusion Mutants of the Influenza Virus Hemagglutinin Glycoprotein", Cell 40, 431-439, 1985.
    
    
47. Daniels, R.S., Skehel, J.J., and Wiley, D.C. Amino Acid Sequences of Haemagglutinins of Influenza Viruses of the H3 Subtype Isolated from Horses, J. Gen. Virol. 66, 457, 1985.
    
    
48. Daniels, R.S., Douglas, A.R., Skehel, J.J., and Wiley, D.C. Antigenic and Amino Acid Sequence Analyses of Influenza Viruses of the H1N1 Subtype Isolated Between 1982 and 1984, Bulletin of the World Health Organization 63, 273, 1985.
    
    
49. Skehel, J.J., Brown, E., Daniels, R.S., Douglas, A.R., Knossow, M., Wilson, I.A., Wrigley, N.G., and Wiley, D.C. Studies with Monoclonal Antibodies Prepared Against X-31 Influenza Virus Haemagglutinin, Biochem. Soc. Trans. 13, 12, 1985.
    
    
50. Daniels, R.S., Douglas, A.R., Gonsalves-Scarano, F., Palu, G., Skehel, J.J., Brown, E., Knossow, M., Wilson, I.A., and Wiley, D.C. Antigenic Structure of Influenza Virus Haemagglutinin, in The Origin of Pandemic Influenza Viruses (eds. Laver, G. W. and Chu, C. M., Elsevier-North Holland, New York, 1985.
    
    
51. Daniels, R.S., Douglas, A.R., Skehel, J.J., Waterfield, M.D., Wilson, I.A., and Wiley, D.C. Studies of the Influenza Virus Haemagglutinin in the pH5 Conformation, in The Origin of Pandemic Influenza Viruses eds. Laver, G.W. and Chu, C.M., Elsevier-North Holland, New York), pp. 1-7, 1985.
    
    
52. Skehel, J.J., Daniels, R.S., Hay, A.J., Ruigrok, R., Wharton, S.A., Wrigley, N.G., Weis, W. and Wiley, D.C. Structural Changes in Influenza Virus Haemagglutinin at the pH of Membrane Fusion, Biochem. Soc. Trans., 14, 1986.
    
    
53. Bjorkman, P.J., Strominger, J.L., and Wiley, D.C. Crystallization and X-ray Diffraction Studies on the Histocompatibility Antigens HLA-A2 and HLA-A28 from Human Cell Membranes, J. Mol. Biol. 186, 205- 210, 1985.
    
    
54. Wharton, S.A., Skehel, J.J, and Wiley, D.C. Studies of Influenza Haemagglutinin-Mediated Membrane Fusion, Virology 149, 27-35, 1986.
    
    
55. Murre, C., Parker, K.C., Reiss, C.S., Driller, J.P., Wiley, D.C., Burakoff, S.J., and Seidman, J.G. Biochemical and Functional Analyses of a Secreted H-2Ld Molecule, Mol. and Cell. Biol., 1315-1319, April, 1986.
    
    
56. Durbin, R., Burns, R., Moulai, J., Metcalf, P., Freymann, D., Blum, M., Anderson, J., Harrison, S.C., and Wiley, D.C. Protein, DNA, and Virus Crystallography with a Focused Imaging Proportional Counter, Science 232, 1127-1132, 1986.
    
    
57. Wang, M.L., Skehel, J.J., and Wiley, D.C. Comparative Analyses of the Specificities of Anti- influenza Haemagglutinin Antibodies in Human Sera, J. Virol. 57, 124, 1986.
    
    
58. Skehel, J.J. and Wiley, D.C. Antigenic Variation in Hong Kong Influenza Virus Haemagglutinins,. Antigenic Variation in Infectious Diseases (eds. Birbeck, T.H., and Penn, C.W.), IRL Press, Oxford, 19-24, 1986.
    
    
59. Knossow, M., Lewis, M., Rees, D., Wilson, I.A., Skehel, J.J. and Wiley, D.C. The Refinement of the Haemagglutinin Membrane Glycoprotein on Influenza Virus. Acta Cryst. B42, 627- 632, 1986.
    
    
60. Ruigrok, R.W.H., Martin, S.R., Wharton, S.A., Skehel, J.J., Bayley, P.M., and Wiley, D.C. Conformational Changes in the Hemagglutinin of Influenza Virus Which Accompany Heat- Induced Fusion of Virus with Liposomes, Virology 155, 484-497, 1986.
    
    
61. Underwood, P.A., Skehel, J.J., and Wiley, D.C. Receptor Binding Characteristics of Monoclonal Antibody-Selected Antigenic Variants of Influenza Virus, J. Virol. 61, 206-208, 1987.
    
    
62. Wiley, D.C. and Skehel, J.J. The Structure and Function of the Hemagglutinin Membrane Glycoprotein of Influenza Virus, Ann. Rev. Biochem. 56, 365-394, 1987.
    
    
63. Metcalf, P., Blum, M. Freymann, D., Turner, M., and Wiley, D. C. Two Variant Surface Glycoproteins of Trypanosoma Brucei of Different Sequence Classes Have Similar 6 Å Resolution X-ray Structures, Nature 325, 84-86, 1987.
    
    
64. Blum, M., Metcalf, P., Harrison, S.C., and Wiley, D.C. A System for Collection and On-line Integration of X-ray Diffraction Data from a Multiwire Area Detector, J. of Appl. Cryst. 20, 235- 242, 1987.
    
    
65. Daniels, R.S., Jeffries, S., Yates, P., Schild, G.C., Rogers, G.N., Paulson, J.C., Wharton, S.A., Douglas, A.R., Skehel, J.J. and Wiley, D.C. The receptor-binding and membrane- fusion properties of influenza virus variants selected using anti-haemagglutinin monoclonal antibodies, The EMBO J. 6, 1459- 1465, 1987.
    
    
66. Stevens, D.J., Douglas, A.R., Skehel, J.J. and Wiley, D.C. Antigenic and Amino Acid Sequence Analysis of the 1986 H1N1 Influenza Virus Variants, Bulletin of the World Health Organization, 65, 177-180, 1987.
    
    
67. Skehel, J.J. and Wiley, D.C., Influenza Hemagglutinin, Chapter: 9, Biological Organization: Macromolecular Interactions at High Resolution (eds. R.M. Burnett and H.J. Vogel), Academic Press, 135-138, 1987.
    
    
68. Bjorkman, P.J., Saper, M., Samraoui, B., Bennett, W., Strominger, J.L. and Wiley, D.C. Structure of the Human Class I Histocompatibility Antigen, HLA-A2, Nature 329, 506-512, 1987.
    
    
69. Bjorkman, P.J., Saper, M., Samraoui, B., Bennett, W., Strominger, J.L. and Wiley, D.C. The Foreign Antigen Binding Site and T Cell Recognition Regions of Class I Histocompatibility Antigens. Nature 329, 512-518, 1987.
    
    
70. Brown, J.H., Jardetzky, T., Saper, M.A., Samraoui, B., Bjorkman, P.J. and Wiley, D.C. A Hypothetical Model of the Foreign Antigen Binding Site of Class II Histocompatibility Molecules, Nature 332, 845-850, 1988.
    
    
71. Weis, W., Brown, J., Cusack, S., Paulson, J.C., Skehel, J.J. and Wiley, D.C. The Structure of the Influenza Virus Haemagglutinin Complexed With Its Receptor, Sialic Acid, Nature 333, 426-431, 1988.
    
    
72. Ajitkumar, P., Geier, S.S., Kesari, K.V., Borriello, F., Nakagawa, M., Bluestone, J.A., Saper, M.A., Wiley, D.C. and Nathenson, S.G. Evidence that Multiple Residues on Both the a-Helices of the Class I MHC Molecule are Simultaneously Recognized by the T Cell Receptor, Cell 54, 47- 56, 1988.
    
    
73. Ruigrok, R.W.H., Aitken, A., Calder, L.J., Martin, F.R., Skehel, J.J., Wharton, S.A., Weis, W. and Wiley, D.C. Studies on the Structure of the Influenza Virus Haemagglutinin at the pH of Membrane Fusion, J. Gen. Virol. 69, 2785-2795, 1988.
    
    
74. Wharton, S.A., Ruigrok, R.W.H., Martin, S.R., Skehel, J.J., Bayley, P.M., Weis, W. and Wiley, D.C. Conformational Aspects of the Acid-induced Fusion Mechanism of Influenza Virus Hemagglutinin. Circular Dichroism and Fluorescence Studies, J. Biol. Chem. 263, 4474-4480, 1988.
    
    
75. Metcalf, P., Down, J.A., Turner, J.J. and Wiley, D.C. Crystallization of Amino Terminal Domains and Domain Fragments of Variant Surface Glycoproteins, J. Biol. Chem. 263, 17030- 17033, 1988.
    
    
76. Wharton, S.A., Martin, S.R., Ruigrok, R.W.H., Skehel, J.J. and Wiley, D.C. Membrane Fusion by Peptide Analogues of Influenza Virus Haemagglutinin, J. Gen. Virol. 69 1847- 1857, 1988.
    
    
77. Skehel, J. J. and Wiley, D. C. Antigenic Variation in Influenza Virus Haemagglutinins. RNA Genetics: Variability of RNA Genomes . (E. Domingo, J. J. Holland and P. Ahlquist, eds.) CRC Press, Inc.:Boca Raton. Volume III, 139- 146, 1988.
    
    
78. Garrett, T.P.J., Saper, M.A., Samraoui, B., Bjorkman, P.J. and Wiley, D.C. Structure/Function Studies of Major Histocompatibility Antigens, Transplantation Proceedings 21, 588- 590, 1989.
    
    
79. Sauter, N.K., Bednarski, M.D., Wurzburg, B.A., Hanson, J.E., Whitesides, G.M., Skehel, J.J. and Wiley, D.C. Hemagglutinins from Two Influenza Virus Variants Bind to Sialic Acid Derivatives with Millimolar Dissociation Constants: A 500 MHz Proton Nuclear Magnetic Resonance Study, Biochemistry 28, 8388-8396, 1989.
    
    
80. Schawaller, M., Smith, G.E., Skehel, J.J. and Wiley, D.C. Studies with Crosslinking Reagents on the Oligomeric Structure of the env Glycoprotein of HIV, Virology 172, 367-369, 1989.
    
    
81. Parker, K.C. and Wiley, D.C. Overexpression of Native Human__2-microglobulin in Escherichia coli and its purification, Gene 83, 117-124, 1989.
    
    
82. Garrett, T.P.J., Saper, M.A., Bjorkman, P.J., Strominger, J.L., and Wiley, D.C. Specificity Pockets for the Side Chains of Peptide Antigens in HLA-Aw68, Nature 342, 692-696, 1989.
    
    
83. Wharton, S.A., Weis, W., Skehel, J.J. and Wiley, D.C. Structure, Function, and Antigenicity of the Hemagglutinin of Influenza Virus in The Influenza Viruses. R. M. Krug, ed., Plenum Publishing Corp., NY, 1989.
    
    
84. Madden, D.R., Saper, M.A., Garrett, T.P.J., Bjorkman, P.J., Strominger, J.L. and Wiley, D.C. A Comparison of Orthorhombic and Monoclinic Crystal Structures of HLA-A2, Cold Spring Harbor Labs Symposium on Quantitative Biology 54, 353-359, 1989.
    
    
85. Jardetzky, T.S., Gorga, J.C., Busch, R., Rothbard, J., Strominger, J.L. and Wiley, D.C. Purification of Complexes Between Peptide Antigens and Class II Major Histocompatibility Complex Antigens Using Biotinylated Peptides in Proceedings of the 10th Course of the International School of Pure and Applied Biostructure: Protein Structure and Engineering, Plenum Press, 1989.
    
    
86. Wiley, D.C. and Skehel, J.J. Viral Membranes in Virology. B.N. Fields, D.M. Knipe et al., Raven Press, Ltd., New York, 63-85, 1990.
    
    
87. Weis, W.I., Cusack, S.C., Brown, J.H., Daniels, R.S., Skehel, J.J. and Wiley, D.C. The Structure of a Membrane Fusion Mutant of the Influenza Virus' Haemagglutinin, EMBO J. 9, 17- 24, 1990.
    
    
88. Wiley, D.C. Structural Molecular Biology of Two Membrane Recognition Events, The Harvey Lectures, Series 84, 19-26, 1990.
    
    
89. Weis, W.I., Brunger, A.T., Skehel, J.J. and Wiley, D.C. Refinement of the Influenza Virus Haemagglutinin by Simulated Annealing, J. Mol. Biol. 212,737- 761, 1990.
    
    
90. Jardetzky, T.S., Gorga, J.C., Busch, R., Rothbard, J., Strominger, J.L. and Wiley, D.C. Peptide Binding to HLA-DR1: A Peptide with Most Residues Substituted to Alanine Retains MHC Binding, EMBO J. 9, 1797-1803, 1990.
    
    
91. Wiley, D.C. Structure/Function Studies on Membrane Proteins from Human Cells, The Trypanosome Parasite and Influenza Virus. The Robert A. Welch Foundation Conference on Chemical Research Proceedings XXXIII Membrane Proteins: Targeting and Transduction. Welch Conference, Houston, Texas, Chapter VIII. 161-179, 1990.
    
    
92. Wiley, D.C. Recognition at Membrane Surfaces: Influenza HA and Human HLA in Protein Design and the Development of New Therapeutics and Vaccines. J.B. Hook and G. Poste (eds., Plenum Publishing:New York, 449-475, 1990.
    
    
93. Chen, J., Skehel, J., and Wiley, D.C. A Polar Octapepeptide Fused to the N- Terminal Fusion Peptide Solubilizes the Influenza Virus HA2 Subunit Ectodomain. Biochemistry 37, no. 39, 13643-13649, 1998.
    
    
94. Zhou G., Ferrer, M., Chopra R., Kapoor T., Strassmeier, T., Weissenhorn, W., Skehel, J., Oprian D., Schreiber S., Harrison, S., and Wiley, D.C. The Structure of HIV-1 Specific Cell Entry Inhibitor in Complex with the HIV-1 Trimeric Core, Bioorganic and Medicinal Chemistry 8, 2219-2227, 2000.
    
    
95. Calder, L., Gonzalez-Reyes L., Garcia-Barreno, B., Wharton, S., Skehel, J., Wiley, D.C., and Melero, J. Electron Microscopy of the Human Respiratory Syncytial Virus Fusion Protein and Complexes That It Forms with Monoclonal Antibodies, Virology 271 (1), 122-131, 2000.
    
    
96. Cross, K., Wharton, S., Skehel, J., Wiley, D.C., Steinhauer., D. Studies on Influenza Haemagglutinin Fusion Peptide Mutants Generated by Reverse Genetics, EMBO J., 20 (16), 4432- 4442, 2001
    
    
97. González-Reyes, Begoña-Ruiz-Argüello, M., García-Barreno B., Calder L., López, Albar, J., Skehel J., Wiley D.C., Melero, J. Cleavage of the Human Respiratory Syncitial Virus Fusion Protein at Two Distinct Sites is Required for Activation of Membrane Fusion, PNAS 98, 9859-9864, 2001.
    
    
98. Fan, Q., Long, E., and Wiley, D.C. Crystal Structure of the Human Natural Killer Cell Inhibitory Receptor KIR2DLI-HLA-Cw4 Complex, Nature Immunology, 2 (5), 452-460, 2001.
    
    
99. Gewurz, B, Gaudet, R., Tortorella, D., Wang, E., Ploegh, H., and Wiley, D.C., Antigen Presentation Subverted: Structure of the Human Cytomegalovirus Protein US2 Bound to the Class I Molecule HLA-A2, PNAS, 98, 6794-6799, 2001.
    
    
100. Lin., Y., Wharton, S., Martín, Skehel, J., Wiley, D.C., and Steinhauer, D. Adaptation of Egg-Grown and Trasfectant Influenza Viruses for Growth in Mmmalian Cells: Selection of Hemagglutinin Mutants with Elevated pH of Membrane Fusion, Virology 233, 402-410,1997.
     
     
101. Freymann, D., Down, J., Carrington, M., Roditi, I., Turner, M. and Wiley, D.C. The 2.9Å Resolution Structure of the N-terminal Domain of a VSG from Trypanosoma brucei, J. Mol. Biol. 216, 141-160, 1990.
     
     
102. Silver, M., Parker, K. and Wiley, D.C. Reconstitution by MHC-restricted Peptides of HLA- A2 Heavy Chain with _2-microglobulin, in vitro, Nature 350, 619-622, 1991.
     
     
103. Down, J.A., Garman, S.C., Gurnett, A.M., Turner, M.J. and Wiley, D.C. Crystallization and Preliminary X-Ray Analysis of an Intact Soluble-Form Variant Surface Glycoprotein from The African Trypanosome, T. Brucei1, J. Mol. Biol. 218, 679- 683, 1991.
     
     
104. Saper, M.A., Bjorkman, P.J., and Wiley, D. C. Refined Structure of the Human Histocompatibility Antigen HLA-A2 at 2.6 Å Resolution, J. Mol. Biol. 219, 277- 319, 1991.
     
     
105. Madden, D.R., Gorga, J.C., Strominger, J.L. and Wiley, D.C. The Structure of HLA- B27 Reveals Nonamer 'Self-Peptides' Bound in an Extended Conformation, Nature 353, 321-325, 1991.
     
     
106. Jardetzky, T.S., Lane, W.S., Robinson, R.A., Madden, D.R. and Wiley, D.C. Identification of Self Peptides Bound to Purified HLA-B27, Nature 253, 326-329, 1991.
     
     
107. Carrington, M., Miller, N., Blum, M., Roditi, I., Wiley, D.C. and Turner, M. The Variant Specific Glycoprotein of Trypanosoma brucei Consists of Two Domains Each Having an Independently Conserved Pattern of Cysteines, J. Mol. Biol. 221, 823-835, 1991.
     
     
108. Steinhauer, D.A., Wharton, S.A., Wiley, D.C. and Skehel, J.J. Deacylation of the Haemagglutinin of Influenza A/Aichi/2/68 has no Effect on Membrane Fusion, Virol. 184, 445- 448, 1991.
     
     
109. Gorga, J.C., Brown, J.H., Jardetzky, T.S., Wiley, D.C. and Strominger, J.L. Crystallization of HLA-DR Antigens, Res. Immunol. 142, 401-407, 1991.
     
     
110. Glick, G.D., Toogood, P.L., Wiley, D.C., Skehel, J.J. and Knowles, J.J. Ligand Recognition by Influenza Virus, J. of Biol. Chem. 266, 23660-23669, 1991.
     
     
111. Steinhauer, D.A., Wharton, S.A., Skehel, J.J., Wiley, D.C. and Hay, A.J. Amantadine Selection of a Mutant Influenza Virus Containing an Acid-Stable Hemagglutinin Glycoprotein: Evidence of Virus-specific Regulation of pH of Glycoprotein Transport Vesicles, Proc. Natl. Acad. Sci. USA 88, 11525-11529, 1991.
     
     
112. Pollard, S.R., Meier, W., Chow, P., Rosa, J.J. and Wiley, D.C. CD4 Binding Regions of gp120 Defined by Proteolytic Digestion, Proc. Natl. Acad. Sci. USA 88, 11320- 11324, 1991.
     
     
113. Gorga, J.C., Madden, D.R., Prendergast, J.K., Wiley, D.C. and Strominger, J.L. Crystallization and Preliminary X-Ray Diffraction Studies of the Human Major Histocompatibility Antigen HLA-B27+, Proteins 12, 87-90, 1992.
     
     
114. Stern, L.J. and Wiley, D.C. The Human Class II MHC Protein HLA-DR1 Assemblies as Empty __ Heterodimers in the Absence of Antigenic Peptide, Cell 68, 465-477, 1992.
     
     
115. Sauter, N.K., Glick, G.D., Crowther, R.L., Park, S-J, Eisen, M.B., Skehel, J.J., Knowles, J.R. and Wiley, D.C. Crystallographic Detection of a Second Ligand Binding Site in Influenza Virus Hemagglutinin, Proc. Natl. Acad. Sci. USA 89, 324-328, 1992.
     
     
116. Pollard, S.R., Rosa, M.D., Rosa, J.J. and Wiley, D.C. Truncated Variants of gp120 Bind CD4 with High Affinity Suggest a Minimum CD4 Binding Region, EMBO J. 11, 585-591, 1992.
     
     
117. Godley, L., Pfeifer, J., Steinhauer, D., Shaw, G., Kaufmann, R., Suchanek, E., Pabo, C., Ely, B., Skehel, J.J., Wiley, D.C. and Wharton, S. Introduction of Intersubunit Disulfide Bonds in the Membrane-Distal Region of the Influenza Hemagglutinin Abolishes Membrane Fusion Activity, Cell 68, 635-645, 1992.
     
     
118. Parker, K.C., Silver, M.L. and Wiley D.C. An HLA-A2/_2- microglobulin/peptide complex assembled from Subunits Expressed Separately in Escherichia coli, Mol. Immun. 29, 371-378, 1992.
     
     
119. Garboczi, D.N., Hung, D.T. and Wiley, D.C. HLA-A2-Peptide Complexes: Refolding and Crystallization of Molecules Expressed in Escherichia coli and Complexed with Single Antigenic Peptides, Proc. Natl. Acad. Sci. USA 89, 3429-3433, 1992.
     
     
120. Madden, D.R. and Wiley, D.C. Peptide Binding to The Major Histocompatibility Complex Molecules, Current Biology 2, 300-304, 1992.
     
     
121. Hanson, J.E., Sauter, N.K., Skehel, J.J., and Wiley, D.C. Proton Nuclear Magnetic Resonance Studies of the Binding of Sialosides to Intact Influenza Virus, Virology 189, 525-533, 1992.
     
     
122. Madden, D.R., Gorga, J.C., Strominger, J.L. and Wiley, D.C. The Three- dimensional Structure of HLA- B27 at 2.1Å Resolution Suggests a General Mechanism for Tight Peptide Binding to MHC, Cell 70, 1035- 1048, 1992.
     
     
123. Sauter, N.K., Hanson, J.E., Glick, G.D., Brown, J.H., Crowther, R.L., Park, S- J., Knowles, J.R., Skehel, J.J., and Wiley, D.C. Binding of Influenza Virus Hemagglutinin to Analogs of its Cell-Surface Receptor, Sialic Acid: Analysis by Proton Nuclear Magnetic Resonance Spectroscopy and X-ray Crystallography, Biochemistry 31, 9609-9621, 1992.
     
     
124. Guo, H-C., Jardetzky, T.S., Garrett, T.P.J., Lane, W.S., Strominger, J.L. and Wiley, D.C. Different Length Peptides Bind to HLA-Aw68 Similarly at Their Ends but Bulge out in the Middle. Nature 360, 364- 366, 1992.
     
     
125. Silver, M.L., Guo, H-C., Strominger, J. L. and Wiley, D.C. Atomic Structure of a Human MHC Molecule Presenting an Influenza Virus Peptide. Nature 360, 367-369, 1992.
     
     
126. Steinhauer, D.A., Sauter, N.K., Skehel, J.J. and Wiley, D.C. Receptor binding and cell entry by influenza viruses, Seminars in Virology. 3, 91-100, 1992.
     
     
127. Blum, M.L., Down, J.A., Gurnett, A.M., Carrington, M., Turner, M.J. and Wiley, D.C. A Structural Motif in the Variant Surface Glycoproteins of Trypanosoma brucei, Nature 362, 603- 609, 1993
     
     
128. Brown, J.H., Jardetzky, T.S., Gorga, J.C., Stern, L.J., Urban, R.G., Strominger, J.L. and Wiley, D.C. The Three-Dimensional Structure of the Human Class II Histocompatibility Antigen HLA- DR1. Nature 364, 33-39, 1993.
     
     
129. Guo, H.-C., Madden, D.R., Silver, M.L., Jardetzky, T.S., Gorga, J.C., Strominger, J.L. and Wiley, D.C. Comparison of the P2 Specificity Pocket in Three Human Histocompatibility Antigens: HLA-A*6801, HLA- A*0201 and HLA-B*2705. Proc. Natl. Acad. Sci. USA, 90, 8053- 8057, 1993.
     
     
130. Madden, D.R., Garboczi, D.N. and Wiley, D.C. The Antigenic Identity of Peptide-MHC Complexes: A Comparison of the Conformations of Five Viral Peptides Presented by HLA-A2. Cell 75, 693-708, 1993.
     
     
131. Stern, L.J., Brown, J.H., Jardetzky, T.S. and Wiley, D.C. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368, 215-221, 1994.
     
     
132. Bullough, P.A., Hughson, F.M., Treharne, A.C., Ruigrok, R.W.H., Skehel, J.J. and Wiley, D.C. Crystals of a Fragment of Influenza Haemagglutinin in the Low pH Induced Conformation. J. Mol. Biol., 236, 1262-1265, 1994.
     
     
133. Jardetzky, T.S., Brown, J.H., Gorga, J.C., Stern, L.J., Urban, R.G., Chi, Y.- i., Stauffacher, C., Strominger, J.L., Wiley, D. C. The Three-Dimensional Structure of a Human Class II Histocompatibility Molecule:Superantigen Complex. Nature 368, 711-718, 1994.
     
     
134. Stern, L.J. and Wiley, D.C. Antigenic Peptide Binding by Class I and Class II Histocompatibility Proteins. Structure, 2, 245-251, 1994.
     
     
135. Garboczi, D.N., Madden, D.R. and Wiley, D.C. Five Viral Peptide-HLA-A2 Co- crystals: Simultaneous Space Group Determination and X-ray Data Collection, J. Mol. Biol. 239, 581-587, 1994.
     
     
136. Seth, A.H., Stern, L.J., Ottenhoff, T.H.M., Engel, I., Owen, M.J., Lamb, J.R., Klausner, R.D. and Wiley, D.C. Binary and Tertiary Complexes Between T-cell receptor, class II MHC and superantigen in vitro, Nature, 369, 324-327, 1994.
     
     
137. Eisen, M.B., Wiley, D.C., Karplus, M., and Hubbard, R. E. HOOK: A Program for Finding Novel Molecular Architectures that Satisfy the Chemical and Steric Requirements of a Macromolecule Binding Site. Proteins, 19, 199-221, 1994.
     
     
138. Bouvier, M. and Wiley, D.C. Importance of an Antigenic Peptide N- and C- termini to the Stability of Class I MHC Molecules. Science, 265, 398-402, 1994.
     
     
139. Watowich, S.J., Skehel, J.J. and Wiley, D.C. Crystal structures of influenza virus hemagglutinin in complex with high-affinity receptor analogs, Structure, 2, 719-731, 1994.
     
     
140. Sadegh-Nasseri, S., Stern, L.J., Wiley, D.C. and Germain, R.N. MHC Class II Function by Low-affinity Peptide Interactions Preceding Stable Binding, Nature, 370, 647-650, 1994.
     
     
141. Bullough, P.A., Hughson, F.M., Skehel, J.J. and Wiley, D.C. The Structure of the Influenza Haemagglutinin at the pH of Membrane Fusion, Nature, 371, 37-43, 1994.
     
     
142. Collins, E.J., Garboczi, D.N. and Wiley, D.C. Three Dimensional Structure of a Peptide Extending Out One End of a Class I MHC Binding Site, Nature, 371, 626-629, 1994.
     
     
143. Kim, J., Urban, R.G., Strominger, J.L., and Wiley, D.C. Toxic Shock Syndrome Toxin-1 Complexed with a Class II Major Histocompatibility Molecule, HLA-DR1, Science, 266, 1870- 1874, 1994.
     
     
144. Skehel, J.J., Steinhauer, D.A., Wharton, S.A., Bullough, P.A., Hughson, F.M., Watowich, S.J. and Wiley, D.C. Receptor binding and membrane fusion by influenza hemagglutinin. In: "Cellular Receptors for Animal Viruses", Cold Spring Harbor Laboratory Press, pp. 187-193, 1994.
     
     
145. Wharton, S.A., Calder, L.J., Ruigrok, R.W.H., Skehel, J.J., Steinhauer, D.A. and Wiley, D.C. Electron Microscopy of Antibody Complexes of Influenza Virus Haemagglutinin in the Fusion pH Conformation. EMBO J., 14, 240-246, 1995.
     
     
146. Watowich, S.J., Skehel, J.J. and Wiley, D.C. Cryocrystallography of Influenza Virus Hemagglutinin Crystals. Acta Cryst. D51, 7-12, 1995.
     
     
147. Collins, E.J., Garboczi, D.N., Karpusas, M.N. and Wiley, D.C. The Three- Dimensional Structure of a Class I Major Histocompatibility Complex Molecule Missing the _3 Domain of the Heavy Chain, Proc. Natl. Acad. of Sci., USA, 92, 1218-1221, 1995.
     
     
148. Weiss, G.A., Collins, E.J., Garboczi, D.N., Wiley, D.C. and Schreiber, S.L. A tricyclic ring system replaces the variable regions of peptides presented by three alleles of human MHC Class I molecules, Chemistry & Biology, 2, 401-407, 1995.
     
     
149. Strominger, J.L. and Wiley, D.C. The class I and class II proteins of the human major histocompatibility complex, JAMA, 274, 1074-1076, 1995.
     
     
150. Jasanoff, A., Park, S.-J. and Wiley, D.C. Direct Observation of Disordered Regions in the Major Histocompatibility Complex Class II-associated Invariant Chain., Proc. Natl. Acad. of Sci., USA, 92, 9900- 9904, 1995.
     
     
151. Park, S.-J., Sadegh-Nasseri, S. and Wiley, D.C. Invariant Chain Made in E. coli has an Exposed N-Terminal Segment That Blocks Antigen Binding to HLA-DR1 and a Trimeric C- Terminal that Binds Empty DR1, Proc. Natl. Acad. of Sci., USA, 92, 11289-11293, 1995.
     
     
152. Steinhauer, D.A., Wharton, S.A., Skehel, J.J. and Wiley, D.C. Studies of the Membrane Fusion Activities of Fusion Peptide Mutants of Influenza Hemagglutinin, J. of Virology, 69, 6643- 6651, 1995.
     
     
153. Ghosh, P., Amaya, M., Mellins, E. and Wiley, D.C. The structure of an intermediate in class II MHC maturation, HLA-DR3, complexed with the invariant chain fragment CLIP, Nature 378, 457-462, 1995.
     
     
154. Brown, J.H, Jardetzky, T.S., Stern, L.J., Gorga, J.C., Strominger, J.L. and Wiley, D.C. Human Class II MHC Molecule HLA-DR1: X-ray Structure Determined from Three Crystal Forms. Acta Cryst. D51, 946-961, 1995.
     
     
155. Skehel, J.J., Bizebard, T., Bullough, P.A., Hughson, F.M., Knossow, M., Steinhauer, D.A., Wharton, S.A. and Wiley, D.C. Membrane Fusion by influenza hemagglutinin. In: "Cold Spring Harbor Symposia on Quantitative Biology", Cold Spring Harbor Laboratory Press, Volume 60, pp. 573- 580, 1995.
     
     
156. Chen, J., Wharton, S.A., Weissenhorn, W., Calder, L.J., Hughson, F.M., Skehel, J.J. and Wiley, D.C. A Soluble Domain of the Membrane-Anchoring Chain of Influenza Virus Hemagglutinin, HA2) Folds in Escherichia coli into the low-pH-induced conformation, Proc. Natl. Acad. of Sci., USA 92, 12205- 12209, 1995.
     
     
157. Harrison, S.C., Skehel, J.J. and Wiley, D.C. Virus Structure in Field's Virology, Third Edition, 59- 99. (eds. B.N. Fields, D.M. Knipe, P.M. Howley, et al.) Lippincott-Raven Publishers, Philadelphia, 1996.
     
     
158. Jardetzky, T.S., Brown, J.H., Gorga, J.C., Stern, L.J., Urban, R.G., Strominger, J.L. and Wiley, D.C. Crystallographic Analysis of Endogenous Peptides Associated with HLA-DR1 Suggests a Common, Polyproline II-Like Conformation for Bound Peptides, Proc. Natl. Acad. of Sci., USA, 93, 734-738, 1996.
     
     
159. Takemoto, D., Skehel, J.J., and Wiley, D.C. A Surface Plasmon Resonance Assay for the Binding of Influenza Virus Hemagglutinin to its Sialic Acid Receptor, Virology 217, 452- 458, 1996.
     
     
160. Weissenhorn, W., Wharton, S.A., Calder, L.J., Earl, P.L., Moss, B., Aliprandis, E., Skehel, J.J. and Wiley, D.C. The Ectodomain of HIV-1 Env Subunit Gp41 Forms a Soluble, Alpha-Helical, Rod- Like Oligomer in the Absence of Gp120 and The N-terminal Fusion Peptide, The EMBO Journal 60, 1507-1514, 1996.
     
     
161. Bouvier, M. and Wiley, D.C. Antigenic Peptides Containing Large PEG Loops Designed to Extend Out of the HLA-A2 Binding Site Form Stable Complexes with Class I Major Histocompatibility Complex Molecules, Proc. Natl. Acad. of Sci., USA 93, 4583- 4588, 1996.
     
     
162. Weissenhorn, W., Eck, M.J., Harrison, S.C. and Wiley, D.C. Phosphorylated T Cell Receptor _- Chain and ZAP70 Tandem SH2 Domains Form a 1:3 Complex in vitro, Eur. J. Biochem. 238, 440- 445, 1996.
     
     
163. Fan, Q.R., Garboczi, D.N., Winter, C.C., Wagtmann, N., Long, E.O. and Wiley, D.C. Direct Binding of a Soluble Natural Killer Cell Inhibitory Receptor to a Soluble HLA- Cw4 Class I MHC Molecule, Proc. Natl. Acad. of Sci., USA, 93, 7178-7183, 1996.
     
     
164. Bouvier, M. and Wiley, D.C. Cyclic Peptides Containing PEG in the Ring Structure Form stable Complexes with Class I MHC Molecules, in Peptides: Chemistry, Structure and Biology, Proceedings of the Fourteenth American Peptide Symposium. Pravin T.P. Kaumaya and Robert S. Hodges (eds.), Mayflower Scientific Ltd:England, pp. 782-783, 1996.
     
     
165. Rosenthal, P.B., Fornanowski, F., Treharne, A.C., Newman, J., Skehel, J.J., Meier-Ewert, H. and Wiley, D.C. Crystallization and Preliminary X-ray Diffraction Studies of the Influenza C Virus Glycoprotein Acta Cryst. D52, 1041-1045, 1996.
     
     
166. Weiss, G.A., Valentekovich, R.J., Collins, E.J., Garboczi, D.N., Lane, W.S., Schreiber, S.L. and Wiley, D.C. Covalent HLA-B27/Peptide Complex Induced by Specific Recognition of an Aziridine Mimic of Arginine, Proc. Natl. Acad. of Sci., USA, 93, 10945-10948, 1996.
     
     
167. Garboczi, D.N., Ghosh, P., Utz., U., Fan, Q.R., Biddison, W.E. and Wiley, D.C. Structure of the Complex between Human T Cell Receptor, Viral Peptide, and HLA-A2, Nature 384, 134- 141, 1996.
     
     
168. Steinhauer, D.A., Martín, J., Lin, Y-P., Wharton, S.A., Oldstone, M.B.A., Skehel, J.J. and Wiley, D.C. Studies using double mutants of the conformational transitions in influenza hemagglutinin required for its membrane fusion activity, Proc. Natl. Acad. of Sci., USA, 93, 12873- 12878, 1996.
     
     
169. Kim, J., van Tienhoven, A.E., Garboczi, D.N., Utz, U., Kim, M-Y and Wiley, D.C. Specific Binding of a Soluble Recombinant _-chain T-cell Antigen Receptor to Toxic Shock Syndrome Toxin- 1, a Superantigen. Mol. Cells 6, 590-596, 1996.
     
     
170. Garboczi, D.N., Utz, U., Ghosh, P., Seth, A., Kim, J., van Tienhoven, A.E., Biddison, W.E. and Wiley, D.C. Assembly, Specific Binding, and Crystallization of a Human TCR-__ with an Antigenic Tax Peptide from Human T Lymphotropic Virus Type 1 and the Class I MHC Molecule HLA- A2, Journal of Immunology, 157 5403-5410, 1996.
     
     
171. Weissenhorn, W., Dessen, A., Harrison, S.C., Skehel, J.J. and Wiley, D.C. Atomic Structure of an Ectodomain from HIV-1 gp41, Nature, 387, 426-430, 1997.
     
     
172. Eisen, M.B., Sabesan S. , Skehel, J.J. and Wiley, D.C. Binding of the influenza A virus to cell- surface receptors: Structures of five hemagglutinin-sialyloligosaccharide complexes determined by X-ray crystallography, Virology 232, 19-31, 1997.
     
     
173. Weissenhorn, W., Calder, L.J., Dessen, A., Laue, T., Skehel, J.J. and Wiley, D.C. Assembly of a Rod-Shaped Chimera of a Trimeric GCN4 Zipper and the HIV-1 Gp41 Ectodomain expressed in E. coli, Proc. Natl. Acad. of Sci., USA 94, 6065-6069, 1997.
     
     
174. Steinhauer, D.A., Wiley, D.C. and Skehel, J.J. Viral Membranes.. In: "Principles of Medical Biology", eds. Bittar and Bittar, JAI Press Inc., Volume 9B, pp. 329-351, 1997.
     
     
175. Fan, Q.R., Mosyak, L., Winter, C.C., Wagtmann, N., Long, E.O., and Wiley, D.C. Structure of the inhibitory receptor for human natural killer cells resemble haematopietic receptors, Nature 389, 96, 1997.
     
     
176. Dessen, A., Lawrence, C.M., Cupo, S., Zaller, D.M., and Wiley, D.C. X-ray Crystal Structure of HLA-DR4 (DRA1*0101, DRB1*0401) Complexed with a Peptide from Human Collagen II, Immunity 7, 473-481, 1997.
     
     
177. Steinhauer, D.A., Wiley, D.C. and Skehel, J.J. Viral Membranes. In Principles of Medical Biology, Volume 9B, Chapter 20, Microbiology, pp. 329-351. JAI Press, Inc., 1997.
     
     
178. Skehel, J.J., Barrere, B., Bizebard, T., Eisen, M., Fleury, D., Knossow, M., Wharton, S.A. and Wiley, D.C. Antibody recognition of Influenza Haemagglutinin. In Molecular Approaches to the Control. of Infectious Diseases. pp. 000-000. Eds. F. Brown, D.Burton, P. Doherty, J. Mekalanos & F. Norrby, Cold Spring Harbor Laboratory Press:NY, 1997.
     
     
179. Garboczi, D.N., Ghosh, P., Utz, U., Biddison, W.E. and Wiley, D.C. A trimolecular complex: Production, crystallization, and preliminary X-ray analysis of a human alpha/beta T cell receptor, a peptide, and the I MHC molecular HLA-A2. HLA-Genetic Diversity of HLA Functional Histocompatibility Workshop and Conference (12th IHWC), Vol II: Conference, p.13-17, 1997.
     
     
180. Martín, J., Wharton, S.A., Pin, Y. P., Takemoto, D. K., Skehel, J.J., Wiley, D.C. and Steinhauer, D.A. Studies of the Binding Properties of Influenza Hemagglutinin Receptor-Site Mutants. Virology 241, 101- 111, 1998.
     
     
181. Ding,Y-H., Smith, K.J., Garboczi, D.N., Utz, S., Biddison, W.E., and Wiley, D.C. Two Human T Cell Receptors Bind in a Similar Diagonal Mode to the HLA-A2/Tax Peptide Complex Using Different TCR Amino Acids. Immunity 8 403-411, 1998.
     
     
182. Bouvier, M. and Wiley, D.C. Structural Characterization of a Soluble Partially Folded Class I Major Histocompatibility Heavy Chain/_2m Heterodimer. Nature Structural Biology 5, 377- 384, 1998.
     
     
183. Weissenhorn, W., Calder, L.J., Wharton, S.A., Skehel, J.J. and Wiley, D.C. The Central Structural Feature of the Membrane Fusion Protein Subunit from the Ebola Virus Glycoprotein is a Long Triple Stranded Coiled coil, Proc. Natl. Acad. of Sci., USA 95, 6032- 6036, 1998.
     
     
184. Bouvier, M., Guo, H-C., Smith, K.J. and Wiley, D.C. Crystal structures of HLA- A*0201 complexed with antigenic peptides with either the amino- or carboxyl-terminal group substituted by a methyl group. Proteins: Structure, Function and Genetics 33, 97-106, 1998.
     
     
185. Ding, Y-H., Javaherian, K., Lo, K-M., Chopra, R., Boehm, T., Lanciotti, J., Harris, B.A., Li, Y., Shapiro, R., Hohenester, E., Timpl, R., Folkman, J. and Wiley, D.C. Zinc Dependent Dimers Observed in Crystals of Human Endostatin. Proceedings of the National Academy of Sciences, USA 95 10443-10448, 1998.
     
     
186. Mosyak, L., Zaller, D.M. and Wiley, D.C. The Structure of HLA-DM, the Peptide Exchange Enzyme that Loads Antigen onto Class II MHC Molecules During Antigen Presentation. Immunity 9, 377-383, 1998.
     
     
187. Chen, J., Skehel, J.J. and Wiley, D.C. A Polar Octapeptide Fused to N- terminal Fusion Peptide Solubilizes the Influenza Virus HA2 Subunit Ectodomain. Biochemistry 37, 13643- 13649, 1998.
     
     
188. Gauthier, L., Smith, K.J., Pyrdol, J., Kalandadze, A., Strominger, J.J., Wiley, D.C. and Wucherpfennig, K.W. Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myeline basic protein. Proceedings of the National Academy of Sciences, USA, 95, 11828-11833, 1998.
     
     
189. Smith, K.J., Pyrdol, J., Gauthier, L. Wiley, D.C. and Wucherpfennig, K.W. Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein. J. Exp. Med. 188, 1511-1520, 1998.
     
     
190. Chen, J., Lee, K.-H., Steinhauer, D., Stevens, D., Skehel, J.J. and Wiley, D.C. Structure of the Hemagglutinin Precursor Cleavage Site, a Determinant of Influenza Pathogenicity and the Origin of the Labile Conformation. Cell 95, 409-417, 1998.
     
     
191. Rosenthal, P.B., Zhang, X., Formanowski, F., Fitz, W., Wong, C-H., Meier- Ewert, H., Skehel, J.J. Three Dimensional Structure of the Haemagglutinin-Esterase-Fusion Glycoprotein of Influenza C. Virus. Nature 396, 92-96, 1998.
     
     
192. Weissenhorn, W. Carfí, A., Lee, K-H., Skehel, J.J. and Wiley, D.C. Crystal Structure of the Ebola Virus Membrane Fusion Subunit, GP2, from the Envelope Glycoprotein Ectodomain, Molecular Cell 2, 605-616, 1998.
     
     
193. Jasanoff, A., Wagner, G. and Wiley, D.C. Structure of a trimeric domain of the MHC class II- associated chaperonin and targeting protein Ii. The EMBO J. 17, 6812-6818, 1998.
     
     
194. Skehel, J.J. and Wiley, D.C. Coiled Coils in Both Intracellular Vesicle and Viral Membrane Fusion, Cell 95, 871-874, 1998.
     
     
195. Weissenhorn, W., Dessen, A., Calder, L. J., Harrison, S. C., Skehel, J. J. and Wiley, D. C. Structural basis for membrane fusion by enveloped viruses. Molecular Membrane Biology 16 (1) 3-9, 1999.
     
     
196. Hausmann, S., Biddison, W.E., Smith, K.J., Ding, Y-H., Garboczi, D.N., Utz, U., Wiley, D.C. and Wucherpfennig, K.W. Peptide recognition of two HLA-A2/Tax(11-19) specific T- cell clones in relationship to their MHC/Peptide/TCR crystal structures. J. Immunol. 162, 5389- 5397, 1999.
     
     
197. Zhang, X., Rosenthal, P.B., Formanowski, F., Fitz, W., Wong, C.H., Meier- Ewert, H., Skehel, J.J. and Wiley, D.C. X-ray crystallographic determination of the structure of the influenza C virus haemagglutinin-esterase-fusion glycoprotein. ACTA Cryst D, 55, 945-961, 1999.
     
     
198. Jasanoff, A., Song, S., Dinner, A., Wagner, G. and Wiley, D.C. One of Two Unstructured Domains of Ii Becomes Ordered in Complexes with MHC Class II Molecules, Immunity 10, 761- 768, 1999.
     
     
199. Fan, Q. and Wiley, D.C. Structure of HLA-Cw4, a specific ligand for KIR2D inhibitory NK receptors. J. Exp. Med., 190, 113-123, 1999.
     
     
200. Ding, Y-H., Baker, B.M., Garboczi, D.N., Biddison, W.E. and Wiley, D.C. Four A6- TCR/Peptide/HLA-A2 Structures that Generate Very Different T Cell Signals Are Nearly Identical. Immunity 11, 45-56, 1999.
     
     
201. Chen, J., Skehel, J.J. and Wiley, D.C. N- and C-Terminal Residues combine in the Fusion-pH Influenza HA2 to form a Novel N-Cap that Terminates the Triple-Stranded Coiled Coil Proc of the Natl Aca of Sci, USA 96, 8967-8972, 1999.
     
     
202. Ferrer, M., Kapoor, T., Strassmaier, T., Weissenhorn, W., Skehel, J.J., Oprian, D., Schreiber, S., Wiley, D.C. and Harrison, S.C. Selection of gp41-Mediated HIV-1 Cell Entry Inhibitors From Biased Combinatorial Libraries of Non-Natural Binding Elements. Nat. Struct. Biol. 6, 953-960, 1999.
     
     
203. Carfí, A., Smith, C.A., Smolak, P.J., McGrew, J. and Wiley, D.C. Structure of a soluble secreted chemokine inhibitor vCCI (P35) from Cowpox virus, Proc of the Natl Aca of Sci, USA 96, 12379- 12383, 1999.
     
     
204. Baker, B.M., Ding, Y-H., Garboczi, D.N., Biddison, W.E. and Wiley, D.C. "Structural, Biochemical, and Biophysical Studies of HLA-A2/Altered Peptide Ligands Binding to Viral-peptide specific Human T-cell Receptors." Cold Spring Harbor Symposia on Quantitative Biology: Signaling & Gene Expression in the Immune System, 64, 235-241, 1999.
     
     
205. Khan, A.R., Baker, B.M., Ghosh, P., Biddison, W.E. and Wiley, D.C. "The Structure and Stability of an HLA-A*0201/Octameric Tax Peptide Complex with an Empty Conserved Peptide- N- Terminal Binding Site." J. of Immunology, 164, 6398-6405, 2000.
     
     
206. Wharton, S.A., Skehel, J.J. and Wiley, D.C. Temperature Dependence of Fusion by Sendai Virus. Virology, 271, 71-78, 2000.
     
     
207. Lee, K.H., Olson, G.L., Bolin, D.R., Benowitz, A.B., Sprengeler, P.A., Smith, A.B. III, Hirschmann, R.F. and Wiley, D.C. "The Crystal Structure of a Pyrrolinone-Peptide Hybrid Ligand Bound to the Human Class II MHC Protein HLA-DR1." J of Am Chem Soc, 122, 8370-8375, 2000.
     
     
208. Fan, Q.R., Long, E. O., Wiley, D.C. Cobalt-mediated dimerization of the human natural killer cell inhibitory receptor. J of Biol Chem , 275, 23700-23706, 2000.
     
     
209. Skehel, J. & Wiley, D. Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin. Ann Rev of Biochem 69, 531-569, 2000.
     
     
210. Fan, Q.R., Long, E. O. and Wiley, D.C., A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild type monomer. Eur J. Immunol. 30, 2692-2697, 2000.
     
     
211. Baker, B., Gagnon, Biddison, W. and Wiley, D.C. Conversion of a T Cell Antagonist into an Agonist by Repairing a Defect in the TCR/Peptide/MHC Interface: Implications for TCR Signaling. Immunity 13, 475-484, 2000.
     
     
212. Hennecke, J., Carfi, A. and Wiley, D.C. Structure of a covalently stabilized complex of a human __ T- cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1. EMBO J. 19; 5611-5624, 2000.
     
     
213. Chen, B., Zhou, G., Kim, M., Chishti, Y., Hussey, R.E., Ely, B., Skehel, J.J., Reinherz, E.L., Harrison, S.C. and Wiley, D.C. Expression, Purification, and Characterization of gp160e, the Soluble, Trimeric Ectodomain of the Simian Immunodeficiency Virus Envelope Glycoprotein, gp160. J Biol Chem. 275; 34946-34953, 2000.
     
     
214. Baker, B.M., Turner, R.V., Gagnon, S.J., Wiley, D.C. and Biddison, W.E. Identification of a Crucial Footprint on the _1 Helix of HLA-A2 that Provides Functional Interactions for Recognition by Tax Peptide/HLA-A2-Specific T Cell Receptors. J. Exp. Med., submitted 2000.
     
     
215. Ha Y, Stevens DJ, Skehel JJ, Wiley DC. X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11181-6.
     
     
216. Sliz P, Michielin O, Cerottini JC, Luescher I, Romero P, Karplus M, Wiley DC. Crystal structures of two closely related but antigenically distinct HLA- A2/melanocyte-melanoma tumor-antigen peptide complexes.
     
     
217. Gaudet R, Wiley DC. Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing. EMBO J. 2001 Sep 3;20(17):4964-72.
     
     
218. Carfi A, Willis SH, Whitbeck JC, Krummenacher C, Cohen GH, Eisenberg RJ, Wiley DC. Herpes simplex virus glycoprotein D bound to the human receptor HveA. Mol Cell. 2001 Jul;8(1):169-79.
     
     
219. Cross KJ, Wharton SA, Skehel JJ, Wiley DC, Steinhauer DA. Studies on influenza haemagglutinin fusion peptide mutants generated by reverse genetics. EMBO J. 2001 Aug 15;20(16):4432- 42
     
     
220. Skehel JJ, Cross K, Steinhauer D, Wiley DC. Influenza fusion peptides. Biochem Soc Trans. 2001 Aug;29(Pt 4):623-6. Review.
     
     
221. Hennecke J, Wiley DC. Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity. J Exp Med. 2002 Mar 4;195(5):571-81.
     
     
222. Ha Y, Stevens DJ, Skehel JJ, Wiley DC. H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes. EMBO J. 2002 Mar 1;21(5):865- 875.
     
     
223. Carfi A, Gong H, Lou H, Willis SH, Cohen GH, Eisenberg RJ, Wiley DC. Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA. Acta Crystallogr D Biol Crystallogr. 2002 May; 58 (Pt 5):836-8.
     
     
224. Skehel, J.J. and Wiley D.C., Influenza Haemagglutininin, Vaccine 20, 51-54, 2002.
     
     
225. Stratikos, E., Mosyak, L., Zaller, D., and Wiley, D.C. Identification of the Lateral Interaction Surfaces of Human Histocompatibility Leukocyte Antigen (HLA)-DM with HLA-DR1 by Formation of Tethered Complexes that Present Enhanced HLA-DM Catalyis. Journal of Experimental Medicine (forthcoming), 2002.
     
     
226. Connolly, S.A., Landsburg, D.J., Carfi, A., Wiley, D.C., Eisenberg, R.J. and Cohen, G.H. Structure-based analysis of the herpes simplex virus glycoprotein D binding site present on the herpesvirus entry mediator HveA (HVEM). Submitted 2002.